Structure, biophysics, and circuit function of a “giant” cortical presynaptic terminal

D Vandael, P Jonas - Science, 2024 - science.org
… Thus, the function of the hippocampal mossy fiber synapse may be more complex. … Electron
microscopy analysis revealed that large mossy fiber terminals form multiple active zones, …

[HTML][HTML] Three-dimensional structure of dendritic spines revealed by volume electron microscopy techniques

LK Parajuli, M Koike - Frontiers in Neuroanatomy, 2021 - frontiersin.org
… scanning electron microscopy; SBF-SEM, serial block-face scanning … of mossy fiber inputs
onto CA3 thorny excrescence spines, where multiple synaptic inputs (as many as 37 synaptic

Correlative light and volume electron microscopy to study brain development

S Hayashi, N Ohno, G Knott, Z Molnár - Microscopy, 2023 - academic.oup.com
… as well as in studying complex synaptic connections in thalamic … Serial block-face scanning
electron microscopy (SBF-SEM) [… multiple synapses with the connecting mossy fibre boutons […

Age-related changes in synaptic plasticity associated with mossy fiber terminal integration during adult neurogenesis

KD Murray, XB Liu, AN King, JD Luu, HJ Cheng - Eneuro, 2020 - eneuro.org
electron microscopy (EM), we describe the maturation of … We therefore focused these analyses
on the large complex … In addition, a recent serial block face EM reconstruction analysis in …

Uncovering brain tissue architecture across scales with super-resolution light microscopy

JM Michalska, J Lyudchik, P Velicky, H Korinkova… - bioRxiv, 2022 - biorxiv.org
… tailored analysis of putative synaptic cleft regions. Applying CATS to the hippocampal mossy
fiber … We analyzed complex mossy fiber boutons, but also smaller en passant boutons with …

[HTML][HTML] Imaging brain tissue architecture across millimeter to nanometer scales

JM Michalska, J Lyudchik, P Velicky… - Nature …, 2023 - nature.com
… mouse hippocampal mossy fiber circuitry, we reconstructed and quantified the synaptic input
… This highlights the complex organization of the mossy fiber circuitry, with signal integration …

LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits

J Kim, D Park, NY Seo, TH Yoon… - Proceedings of the …, 2022 - National Acad Sciences
… excitatory synaptic innervation of hippocampal mossy fibers (… ), serial block-face scanning
electron microscopy (SBF-SEM) … The complex structures of individual TEs are displayed by …

Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons

O Kim, Y Okamoto, N Brose, R Shigemoto, P Jonas - bioRxiv, 2023 - biorxiv.org
hippocampal mossy fiber synapses, we performed paired recordings from presynaptic mossy
fiber … with complex changes in both vesicle pool organization and coupling configuration. …

Looking at the Human Brain in Detail

C Bosch - Biological Psychiatry, 2023 - biologicalpsychiatryjournal.com
… that allows staining of electron microscopy (EM) human brain … obtaining complete circuits of
higher complexity—such as those … Within the EM domain, the early description of synapses in …

[HTML][HTML] s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons

T Maruo, K Mizutani, M Miyata, T Kuriu… - Journal of Biological …, 2023 - ASBMB
… A prominent example of a synapse is the hippocampal mossy fiber synapse, a large and
complex … Further, the studies by serial block face-scanning electron microscopy showed that the …